Mesalamine pellets, prepared by an extrusion process and coated with varying concentrations of different pH independent polymers (Ethyl cellulose, Eudragit RLPO and Eudragit RSPO) either alone or in combination were compressed into tablets and their dissolution was compared with a reference product. Morphology of pellets and tablets were studied using SEM and solid state characterized using DSC. SEM studies showed that the coating was smooth and pellets after compression were not fragmented and DSC indicated lack of interaction. Drug release from tablets was inversely proportional to polymer concentration and predominantly followed diffusion kinetics. Composition containing 2% Ethyl cellulose and 3% Eudragit RSPO was able to modulate the release of drug to the desired extent.
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